99% Apixaban CAS 503612-47-3

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale:Apixaban
Lebitso le leng:1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxaMide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,
5-dihydropyrazolo[3,4-c]pyridine-3-carboxaMide
Nomoro ea CAS:503612-47-3
Bohloeki:99%mets
Foromo:C25H25N5O4
Boima ba Molek'hule:459.50
Lintho tsa Lik'hemik'hale:Apixaban ke phofo e tšoeu ea kristale.Ke mofuta o mocha oa oral Xa factor inhibitor, mme lebitso la eona la khoebo ke Eliquis.Apixaban e sebelisetsoa ho phekola bakuli ba baholo ba etsoang opereishene e khethehileng ea letheka kapa lengole ho thibela venous thromboembolism (VTE).

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Tlhaloso

ITEM	TS'ELISO
Ponahalo	E tiileng ho isa ho bosweu
Bohloeki	≥99%

Kopo

Apixaban ke mofuta o mocha oa anticoagulant ea molomo, mofuta o mocha oa oral factor Xa inhibitor, e sebelisetsoang ho thibela le ho phekola mali.
Apixaban ke oral factor Xa inhibitor e ncha e kopantsoeng ke Bristol-Myers Squibb le Pfizer.Ka ho thibela ntho ea bohlokoa ea coagulation Xa, apixaban e thibela moloko oa thrombin le thrombosis.

Ka la 26 Mmesa 2007, Bristol-Myers Squibb le Pfizer ba phatlalalitse nts'etsopele e kopaneng ea anticoagulant apixaban e ncha ea Bristol-Myers Squibb e le mokhoa o ntlafalitsoeng oa warfarin.
Ka May 2011, apixaban e bile eona ea pele ea ho amoheloa bakeng sa thibelo ea venous thrombosis ho bakuli ba baholo ba etsoang opereishene e khethehileng ea letheka kapa lengole linaheng tsa 27 EU, Iceland le Norway.
Ka la 20 November, 2012, Komisi ea Europe e ile ea amohela ELIQUIS (apixaban) bakeng sa thibelo ea ho otloa ke lefu le tsamaiso ea tsamaiso ho batho ba baholo ba nang le non-valvular atrial fibrillation (NVAF) e nang le mabaka a le mong kapa a mangata a kotsi.
Tsamaiso ea Tsamaiso ea Lijo le Lithethefatsi ea Canada, Japane, le Tsamaiso ea Lijo le Lithethefatsi tsa US ka mor'a moo li ile tsa amohela ELIQUIS (apixaban) bakeng sa thibelo ea ho otloa ke lefu le tsamaiso ea tsamaiso ho batho ba baholo ba nang le non-valvular atrial fibrillation (NVAF) e nang le kotsi e le 'ngoe kapa ho feta.
Ka April 12, 2013, ELIQUIS (Apixaban), e ile ea phatlalatsoa ka molao 'marakeng oa Chaena.Apixaban ke novel oral factor Xa inhibitor bakeng sa thibelo ea venous thromboembolism (VTE) ho bakuli ba baholo ba etsoang opereishene ea letheka kapa mangole.Ho qalisoa ha eona ho fana ka khetho e ncha e sireletsehileng le e sebetsang bakeng sa anticoagulation ka mor'a ho buuoa ka masapo mosebetsing oa bongaka, 'me e tlisa litaba tse monate ho bakuli ba Chaena ba nkeloang sebaka sa letheka / lengole.
Liphuputso tsa bongaka li netefalitse hore ha ho bapisoa le 40 mg subcutaneous ente ea enoxaparin hang ka letsatsi, 2.5 mg ea ELIQUIS (Apixaban) ka molomo habeli ka letsatsi e sebetsa hantle ho thibela liketsahalo tsa venous thromboembolic ka mor'a ho buuoa ka letheka kapa lengole, 'me ha e eketse kotsi ea ho tsoa madi.